Mango (Mangifera Indica L.) in the promotion of intestinal regularity and decreases inflammation in human subjects with constipation
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Chronic constipation is a common gastrointestinal condition associated with intestinal inflammation and a considerably impaired quality of life, affecting approximately 1020% of the population in the US. Dietary fiber and laxatives have been shown to aid in the treatment of chronic constipation. In this study, the consumption of mango fruit was compared to an equivalent amount of fiber in its effect on abdominal distention and constipation in otherwise healthy human volunteers. The participants were randomly divided into either the experimental mango group or control fiber group. The mango group consumed 300 g of mango daily for 4 weeks, while the fiber group consumed an equivalent fiber amount (1 teaspoon). Questionnaires regarding intestinal evacuation and digestive wellness were collected weekly, and blood and stool samples were collected at the beginning of the study and after four weeks. The results show that the mango group had better improvement of constipation status as compared to the fiber group, based on evacuation categorization (stool frequency, consistency, and shape). Additionally, increase in gastrin and Peptide YY (PYY) were higher in the mango group than the control fiber group. The production of endotoxin and IL6 were lower in subjects who received mango treatment. In response to the mango intake, two fecal short chain fatty acids, acetic and valeric acid, were increased. Compared to the consumption of fiber, the consumption of mango in the treatment of chronic constipation had higher subject adherence, improved parameters of intestinal evacuation, reduced the production of endotoxins, reduced inflammation, and increased the concentration of short chain fatty acids, all of which have been established to contribute to intestinal health and wellness.Support or Funding InformationMango National Board
