Adaptation of Galloyl Derivatives Metabolism and Excretion After 42 Days of Mango (Mangifera indica L.) Consumption

The absorption, metabolism, and excretion of gallic acid, galloyl glycosides, and gallotannins from mango fruit was assessed in lean and obese subjects who consumed mango continuously for 42 days and compared against a control cohort who consumed mango only on Days 1 and 42. Healthy volunteers (n=21; BMI 2234) consumed 400 g of mango pulp daily for 42 days. Significant (p<0.05) increases were observed in their 24 h urinary excretion of 4Omethylgallic acid3Osulfate, methylpyrogallolOsulfate, pyrogallolOsulfate, and catecholOsulfate. However, no significant differences were observed in the plasma concentrations (AUC08h) for individual metabolites. In the control cohort (n=11; BMI<25) who consumed mango only on Days 1 and 42, no increases were found in the 24 h urinary excretion or plasma comparing concentrations for any of the detected galloyl metabolites on days 1 and 42. Increased metabolism and excretion following daily polyphenol were hypothesized to be due to adaptive increase in the metabolism of gallic acid, galloyl glycosides, and gallotannins by the subjects' gut microbiota. The increased generation of bioactive microbial metabolites may have significant implications for healthbenefits derived from the consumption of gallotanninrich fruits, teas and spices.Support or Funding InformationPartial funding for this research was provided by: National Mango Board

Adaptation of Galloyl Derivatives Metabolism and Excretion After 42 Days of Mango (Mangifera indica L.) Consumption Conference Paper