Transient measurements and analyses of biosensors Conference Paper

abstract

• A theoretical analysis of the transient response of an enzyme electrode to temperature changes is presented. Conventional enzyme electrodes are operated under steady-state conditions and the steady-state current is correlated to the substrate concentration to be measured. However, if the sensor is operated for an extended period of time, the steady-state current changes primarily due to enzyme inactivation. Theoretically the error introduced by this effect can be quantified by operating the biosensor in a temperature pulse mode. It is further shown that this operation may only require a one point calibration and can be extended to the region where the relationship between the steady-state current and the substrate concentration is nonlinear. Finally, a case study of a glucose sensor with temperature pulse is carried out.

authors

• Kravaris, Costas

published proceedings

• AIChE Symposium Series

author list (cited authors)

• Palanki, S., Li, X. M., Kravaris, C., & Wang, H. Y.

complete list of authors

• Palanki, S||Li, XM||Kravaris, C||Wang, HY

publication date

• December 1989

published in

• Aiche Symposium Series  Journal

start page

• 100

end page

• 105

volume

• 85

issue

• 267