A Kinematic Model Coupling Cytoskeletal Dynamics With JNK Activation in Response to Matrix Stretching Conference Paper uri icon


  • Mechanical stretch regulates many cell functions, including proliferation, apoptosis, migration and morphology that occur in response to stretch-induced changes in intracellular signaling and gene expression. We have previously reported that the temporal pattern of stretch-induced JNK activation is highly dependent on the spatiotemporal pattern of stretch that is applied. Specifically, cyclic uniaxial stretch causes a transient activation of JNK that subsides as their actin stress fibers (SFs) become oriented perpendicular to the direction of stretch, while cyclic equibiaxial stretch causes a sustained activation of JNK and does not induce SF orientation (1).

name of conference

  • ASME 2009 Summer Bioengineering Conference, Parts A and B

published proceedings

  • ASME 2009 Summer Bioengineering Conference, Parts A and B

author list (cited authors)

  • Kaunas, R., Huang, Z., & Hahn, J.

citation count

  • 0

complete list of authors

  • Kaunas, Roland||Huang, Zuyi||Hahn, Juergen

publication date

  • January 2009