A NEW PHENOTYPICALLY CONSTRAINED CONTROL POLICY IN BOOLEAN NETWORKS BASED ON BASINS OF ATTRACTION Conference Paper

abstract

• In this paper, a new stationary control policy in Boolean networks (BNs) is derived based on the structural properties of basins of attraction (BOA). The new greedy control policy guarantees that no new attractor cycles will be created by intervention to the original BNs. Hence, it will not introduce significant steady-state mass to ambiguous network states, which may represent unknown phenotypes corresponding to potential collateral damage. Comparing the control performance of this new phenotypically constrained BOA control policy with previous control policies based on long-run network behavior, the experiments based on randomly generated networks have shown that the new control policy obtains competitive performance with reduced complexity. 2012 IEEE.

name of conference

• Proceedings 2012 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)

authors

• Qian, Xiaoning

published proceedings

• Proceedings 2012 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)

author list (cited authors)

• Qian, X.

citation count

• 2

complete list of authors

• Qian, Xiaoning

publication date

• December 2012

publisher

• Institute of Electrical and Electronics Engineers (IEEE)  Publisher

published in

• IEEE International Workshop on Genomic Signal Processing and Statistics : [proceedings]. IEEE International Workshop on Genomic Signal Processing and Statistics  Journal

Digital Object Identifier (DOI)

• 10.1109/gensips.2012.6507725

International Standard Book Number (ISBN) 13

• 9781467352369

start page

• 54

end page

• 57

URL

• http://dx.doi.org/10.1109/gensips.2012.6507725