'Closing the loop' in biological systems modeling - From the in silico to the in vitro Academic Article uri icon


  • This work presents a holistic 'closed loop' approach for the development of models of biological systems. The ever-increasing availability of experimental information necessitates the advancement of a systematic methodology to organise and utilise these data. Herein, we present a biological model building framework that maps the treatment of the information from the initial conception of the model, through its experimental validation and finally to its application in model-based optimisation studies. We highlight and discuss current issues associated with the development of mathematical models of biological systems and share our perspective towards a holistic 'closed loop' approach that will facilitate the control of the in vitro through the in silico. 2011 Elsevier Ltd. All rights reserved.

published proceedings


author list (cited authors)

  • Kiparissides, A., Koutinas, M., Kontoravdi, C., Mantalaris, A., & Pistikopoulos, E. N.

citation count

  • 70

complete list of authors

  • Kiparissides, Alexandros||Koutinas, Michalis||Kontoravdi, Cleo||Mantalaris, Athanasios||Pistikopoulos, Efstratios N

publication date

  • June 2011