Citrus limonoids are unique and effective anticancer agents Conference Paper

abstract

• Although functional only as secondary metabolites in citrus, a class of compounds called limonoids is a family of molecules that have powerful cancer prevention and possibly cancer therapeutic application in human medicine. Postulated to protect plants and fruits from marauding insects and other herbivores, limonoids have the capacity to arrest growth and induce apoptosis in several cancer cell lines in culture. This devastating action is not seen in non-cancerous mammalian epithelial cells. Unbeknown at this time is the mechanism of their fatal action on cancer cells. In this paper, we will review the evidence for limonoid's selective anticancer properties and speculate on the structural features in the molecule that give it this unique action.

authors

• Patil, Bhimanagouda

published proceedings

• PROCEEDINGS OF THE 1ST INTERNATIONAL SYMPOSIUM ON HUMAN HEALTH EFFECTS OF FRUITS AND VEGETABLES

author list (cited authors)

• Harris, E. D., Poulose, S. M., & Patil, B. S.

citation count

• 2

complete list of authors

• Harris, ED||Poulose, SM||Patil, BS

publication date

• May 2007

publisher

• International Society for Horticultural Science (ISHS)  Publisher

published in

• Acta Horticulturae  Journal

keywords

• Apoptosis Induction
• Health-promoting
• Neuroblastoma Cells
• Phytochemicals

Digital Object Identifier (DOI)

• 10.17660/ActaHortic.2007.744.16

International Standard Book Number (ISBN) 13

• 978-90-6605-388-5

start page

• 165

end page

• +

volume

• 744

issue

• 744

URL

• http://dx.doi.org/10.17660/actahortic.2007.744.16