The Effect of Caffeine on Protein Synthesis Rates in Rat Gastrocnemius Muscle Tissue Conference Paper uri icon

abstract

  • BackgroundFew studies have observed caffeine's effects on resistance exercise (RE). Some studies have shown caffeine may affect several key protein synthesis pathways. Since RE is commonly performed to increase muscle protein synthesis, it would be important to determine how caffeine affects protein fractional synthesis rates (FSR).MethodsThirtysix male SpragueDawley rats were assigned into six groups: no exercise no caffeine (NENC), no exercise low caffeine (NELC), no exercise high caffeine (NEHC), exercise no caffeine (ENC), exercise low caffeine (ELC), and exercise high caffeine (EHC). Animals in the exercise groups performed four sessions of jump squats with weighted vests. On each exercise day, caffeine groups were given three caffeine injections (LC: 2mg/kg; HC: 6mg/kg). All animals were given deuterium oxide as a protein tracer on the last RE session, and the gastrocnemius muscle was collected 24 hours later and FSR was analyzed.ResultsFSR was significantly different between exercise and no exercise groups (E: 10.330.49; NE: 8.540.33, p<0.05); however, there was no effect of caffeine intake on FSR (NENC: 8.360.82, NELC: 8.650.75; NEHC: 8.560.82/ ENC: 10.750.75; ELC: 9.990.75; EHC: 10.250.75, p>;0.05).ConclusionOur data suggests that habitual caffeine intake plays little to no role in postRE protein FSR. This observation could be due to an increased tolerance level for caffeine.

published proceedings

  • FASEB JOURNAL

author list (cited authors)

  • Bui, S., Shimkus, K. L., Lee, C. W., Lee, T. V., Chen, V., Fluckey, J. D., & Riechman, S. E.

citation count

  • 0

complete list of authors

  • Bui, Steve||Shimkus, Kevin L||Lee, Chang Woock||Lee, Teak V||Chen, Vincent CW||Fluckey, James D||Riechman, Steve E

publication date

  • April 2013

publisher