How Does Membrane Oxidation Affect Cell Delivery and Cell Killing?

abstract

• The biophysical properties of cellular membranes intimately influence the delivery of cargoes into cells by cell-penetrating peptides (CPPs) and the bactericidal activity of antimicrobial peptides (AMPs). Here, we discuss how lipid oxidation creates important chemical and biophysical changes in membranes, and hypothesize about the observed synergy between oxidized membranes and membrane-active peptides.

authors

• Pellois, Jean-Philippe

published proceedings

• Trends Biotechnol

altmetric score

• 2.95

author list (cited authors)

• Libardo, M., Wang, T., Pellois, J., & Angeles-Boza, A. M.

citation count

• 19

complete list of authors

• Libardo, M Daben J||Wang, Ting-Yi||Pellois, Jean-Philippe||Angeles-Boza, Alfredo M

publication date

• January 2017

publisher

• Elsevier  Publisher

published in

• Trends in Biotechnology  Journal

keywords

• Animals
• Antimicrobial Peptides
• Cell Delivery
• Cell Killing
• Cell Membrane
• Cell-Penetrating Peptides
• Humans
• Lipid Peroxidation
• Membrane Lipids
• Membrane Oxidation
• Oxidation-Reduction

Digital Object Identifier (DOI)

• 10.1016/j.tibtech.2017.03.015

start page

• 686

end page

• 690

volume

• 35

issue

• 8

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2Fj.tibtech.2017.03.015