Modeling cyclic therapy in gene regulatory networks Conference Paper

abstract

• External control of a gene regulatory network is used for the purpose of avoiding undesirable states, such as those associated with disease. Certain types of cancer therapies are given in cycles: each treatment is followed by a recovery phase. In a recovery phase, the side effects tend to gradually degrade. Here, an intervention strategy that simulates cyclic therapies is proposed. It is shown how an optimal cyclic intervention strategy can be devised in the context of probabilistic Boolean networks. The effectiveness of optimal cyclic therapies is shown through numerical studies. 2008 IEEE.

name of conference

• 2008 IEEE International Workshop on Genomic Signal Processing and Statistics

authors

• Chamberland-Tremblay, Jean-Francois
• Datta, Aniruddha
• Dougherty, Edward

published proceedings

• 2008 IEEE INTERNATIONAL WORKSHOP ON GENOMIC SIGNAL PROCESSING AND STATISTICS

author list (cited authors)

• Vahedi, G., Faryabi, B., Chamberland, J., Datta, A., & Dougherty, E.

citation count

• 0

complete list of authors

• Vahedi, Golnaz||Faryabi, Babak||Chamberland, Jean-Francois||Datta, Aniruddha||Dougherty, Edward

publication date

• January 2008

publisher

• Institute of Electrical and Electronics Engineers (IEEE)  Publisher

published in

• IEEE International Workshop on Genomic Signal Processing and Statistics : [proceedings]. IEEE International Workshop on Genomic Signal Processing and Statistics  Journal

keywords

• Cancer
• Gene Therapy
• Genetics

Digital Object Identifier (DOI)

• 10.1109/gensips.2008.4555670

International Standard Book Number (ISBN) 13

• 978-1-4244-2371-2

start page

• 53

end page

• 54

URL

• http://dx.doi.org/10.1109/gensips.2008.4555670