Modelling Oxidative Stress Response Pathways Conference Paper

abstract

• Oxidative stress is a consequence of normal cellular metabolism. The effective functioning of the pathway responding to oxidative stress protects the cellular DNA against oxidative damage and its failure can induce aberrant cellular behaviour leading to diseases such as neurodegenerative disorders and cancer. Thus, understanding the normal signalling present in oxidative stress response pathways and determining possible signalling alterations leading to disease could provide us with useful pointers for therapeutic purposes. Using knowledge of oxidative stress response pathways from the literature, a Boolean network model is developed whose simulated behaviour is consistent with earlier experimental observations from the literature. 2011 IEEE.

name of conference

• 2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)

authors

• Datta, Aniruddha

published proceedings

• 2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)

author list (cited authors)

• Sridharan, S., Layek, R., Datta, A., & Venkatraj, J.

citation count

• 1

complete list of authors

• Sridharan, Sriram||Layek, Ritwik||Datta, Aniruddha||Venkatraj, Jijayanagaram

publication date

• December 2011

publisher

• Institute of Electrical and Electronics Engineers (IEEE)  Publisher

published in

• IEEE International Workshop on Genomic Signal Processing and Statistics : [proceedings]. IEEE International Workshop on Genomic Signal Processing and Statistics  Journal

keywords

• 2 Aetiology
• 2.1 Biological And Endogenous Factors
• Cancer
• Neurodegenerative

Digital Object Identifier (DOI)

• 10.1109/gensips.2011.6169471

International Standard Book Number (ISBN) 13

• 9781467304900

start page

• 166

end page

• 169

URL

• http://dx.doi.org/10.1109/gensips.2011.6169471