Dissolved Core Alginate Microspheres as "Smart-Tattoo" Glucose Sensors Conference Paper uri icon

abstract

  • The feasibility of multilayer thin film coated dissolved-core alginate-templated microsphere sensors based on fluorescence resonance energy transfer and competitive binding, was explored in simulated interstitial fluid, using glucose as a model analyte. The glucose sensitivity was observed to be 0.89%/mM glucose with a linear response in the range of 0-50mM glucose. The sensor response was observed to be completely reversible in nature with a response time of 120 seconds. The system was further demonstrated to respond similarly using near-infrared dyes (Alexa Fluor-647-labeled dextran as donor and QSY-21-conjugated apo-GOx as acceptor) which exhibited a sensitivity of 0.94%/mM glucose with a linear response in range of 0-50mM glucose, making the sensor more amenable to in vivo use, when implanted in scattering tissue. 2009 IEEE.

name of conference

  • 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

published proceedings

  • 2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20

author list (cited authors)

  • Chaudhary, A., Raina, M., McShane, M. J., & Srivastava, R.

citation count

  • 1

complete list of authors

  • Chaudhary, Ayesha||Raina, Monica||McShane, Michael J||Srivastava, Rohit

publication date

  • January 2009