Synthetic peptide combinatorial libraries: a method for the identification of bioactive peptides against phytopathogenic fungi. Academic Article uri icon


  • Synthetic combinatorial libraries were evaluated with an iterative process to identify a hexapeptide with broadspectrum activity against selected phytopathogenic fungi. A D-amino acid hexapeptide (FRLKFH) and pentapeptide (FRLHF) exhibited activity against Fusarium oxysporum f. sp. lycopersici, Rhizoctonia solani (anastomosis group 1), Ceratocystis fagacearum, and Pythium ultimum. The peptides showed no hemolytic or mutagenic activity. Fluorescent microscopy studies with a membrane impermeant dye indicated that fungal cytoplasmic membranes were compromised rapidly and that the nuclear membrane was also affected.

published proceedings

  • Mol Plant Microbe Interact

altmetric score

  • 3

author list (cited authors)

  • Reed, J. D., Edwards, D. L., & Gonzalez, C. F.

citation count

  • 47

complete list of authors

  • Reed, JD||Edwards, DL||Gonzalez, CF

publication date

  • July 1997