Effects of 8 Weeks Ingestion of a Pre-Workout Supplement With and Without Synephrine on Cognitive Function, and Perceptions of Readiness to Perform Conference Paper uri icon


  • Preworkout supplements can increase energy availability and/or exercise capacity. We examined the effects of ingesting a preworkout supplement with and without synephrine for 8w in 78 healthy, resistancetrained men (22 3 y). Subjects were randomly assigned to treatments of: (1) a dextrose flavored placebo (PLA); (2) a supplement containing 3.0 g beta alanine, 2 g creatine nitrate, 2 g arginine AKG, 300 mg of Nacetyl tyrosine, 270 mg caffeine, 15 mg of Mucuna pruriens (PWS) or (3) PWS + 20 mg of synephrine (PWS+S). Primary outcomes: Cognitive function (CF) via a Stroop test. Secondary outcome: Rate of readiness via a visual analogue scale (RTPVAS). Measures were assessed at 0, 4 & 8 w. We used GLM statistical analyses covaried for age and respective baseline measures to determine mean (95% CI) change from baseline. We observed a significant increase in CF for the word test at 4 wks for PWS+S (5.64 count; 2.09, 9.19) and PLA (3.9 count; 0.39, 7.45), and 8 wks for PWS (7.55 count; 4.14, 10.97), PWS+S (9.93 count; 6.48, 13.37) and PLA (6.74 count; 3.31, 10.16). Similar patterns in CF for the color test were noted at 4 wks for PWS (5.05 count; 2.72, 7.38), PWS+S (2.56 count; 0.24, 4.88), PLA (2.76 count; 0.43, 5.09) and 8 wks for PWS (8.3 count; 5.76, 10.89), PWS+S (5.07 count; 2.51, 7.63) and PLA (4.89 count; 2.32, 7.4). Decrease ratings of feelings about 'optimistic about future performance' were observed in all groups at 4 & 8 wks. Results indicate that the preworkout supplement used herein can improve cognitive function.

published proceedings


author list (cited authors)

  • Jung, Y., Cho, M., O'Connor, A., Chang, C., Koozehchian, M., Goodenough, C., ... Kreider, R.

citation count

  • 0

complete list of authors

  • Jung, Y||Cho, M||O'Connor, A||Chang, C||Koozehchian, M||Goodenough, C||Barringer, N||Ayadi, F||Walker, D||Simbo, S||Galvan, E||Dalton, R||Levers, K||Garcia, E||Mitchell, C||Rasmussen, C||Greenwood, M||Murano, P||Earnest, C||Kreider, R

publication date

  • April 2015