Description of a prospective 17DD yellow fever vaccine cohort in Recife, Brazil.
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From September 2005 to March 2007, 238 individuals being vaccinated for the first time with the yellow fever (YF) -17DD vaccine were enrolled in a cohort established in Recife, Brazil. A prospective study indicated that, after immunization, anti-YF immunoglobulin M (IgM) and anti-YF IgG were present in 70.6% (IgM) and 98.3% (IgG) of the vaccinated subjects. All vaccinees developed protective immunity, which was detected by the plaque reduction neutralization test (PRNT) with a geometric mean titer of 892. Of the 238 individuals, 86.6% had IgG antibodies to dengue virus; however, the presence of anti-dengue IgG did not interfere significantly with the development of anti-YF neutralizing antibodies. In a separate retrospective study of individuals immunized with the 17DD vaccine, the PRNT values at 5 and 10 years post-vaccination remained positive but showed a significant decrease in neutralization titer (25% with PRNT titers < 100 after 5 years and 35% after 10 years).
author list (cited authors)
de Melo, A. B., da Silva, M., Magalhes, M., Gonzales Gil, L., Freese de Carvalho, E. M., Braga-Neto, U. M., ... Cordeiro, M. T.
complete list of authors
de Melo, Andréa Barbosa||da Silva, Maria da Paz C||Magalhães, Maria Cecília F||Gonzales Gil, Laura Helena Vega||Freese de Carvalho, Eduardo M||Braga-Neto, Ulisses M||Bertani, Giovani Rota||Marques, Ernesto TA||Cordeiro, Marli Tenório