Optimal Gene Regulatory Network Inference Using the Boolean Kalman Filter and Multiple Model Adaptive Estimation Conference Paper uri icon


  • © 2015 IEEE. We propose a method for the inference of Boolean gene regulatory networks observed through noise. The algorithm is based on the optimal MMSE state estimator for a Boolean dynamical system, known as the Boolean Kalman filter (BKF). In the presence of partial knowledge about the network, a bank of BKFs representing the candidate models is run in parallel in a framework known as Multiple Model Adaptive Estimation (MMAE). Performance is investigated using a model of the p53-MDM2 negative feedback loop network, as well as application to large numbers of random networks in order to estimate average performance.

author list (cited authors)

  • Imani, .., & Braga-Neto, U.

citation count

  • 28

publication date

  • November 2015