Intervention in Biological Phenomena Modeled by S-Systems: A Model Predictive Control Approach Conference Paper uri icon


  • Recent years have witnessed extensive research activity in modeling genetic regulatory networks (GRNs) as well as in developing therapeutic intervention strategies for such networks. S-systems, which offer a good compromise between accuracy and mathematical flexibility, are a promising framework for modeling the dynamical behavior of GRNs, as well as that of biochemical pathways. In this paper, an intervention strategy is proposed for the S-system model. In this approach, a model predictive control algorithm is developed which guides the target variables to their desired values. The proposed intervention strategy is applied to the glycolytic-glycogenolytic pathway as well as a generic branched pathway and the simulation results presented demonstrate the effectiveness of the proposed scheme. 2011 AACC American Automatic Control Council.

name of conference

  • Proceedings of the 2011 American Control Conference

published proceedings


author list (cited authors)

  • Meskin, N., Nounou, H., Nounou, M., Datta, A., & Dougherty, E. R.

citation count

  • 1

complete list of authors

  • Meskin, N||Nounou, H||Nounou, M||Datta, A||Dougherty, ER

publication date

  • June 2011