Localized MRI and histological image correlation in a canine model of duchenne muscular dystrophy.
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abstract
Duchenne Muscular Dystrophy (DMD) is a fatal X-linked disorder. Therapeutic assessments currently require muscle biopsy to ascertain information about the status of disease progression. MRI shows potential to be used in place of muscle biopsy for therapeutic assessments. In this work, localized histological data and various MRI parameters were correlated in a canine model of DMD. The results indicate several MRI parameters may be useful as biomarkers of disease progression.
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2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)