Brain-on-a-chip: An in vitro myelination model Conference Paper

abstract

• 14CBMS. A microfluidic-based neural stem/progenitor cell (NSPC) aggregate culture platform that can be used as an in vitro model system for studying myelinogenesis has been developed. NSPC aggregates of uniform size were obtained using a microfabricated microwell array and were cultured in the microfluidic culture platform at controlled inter-aggregate distances (400, 800, 1600 m). Formation of robust myelin sheaths was observed after 31 days of culture and the microsystem revealed that the expression of myelin sheaths shows dependency on inter-aggregate distances. Also, consistency of the myelin expression in the microsystem enabled investigation of biomolecular treatment effect on myelin expression in vitro.

authors

• Han, Arum
• Kim, Sunja
• Li, Jianrong

published proceedings

• 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

author list (cited authors)

• Park, J., Kim, S., Li, J., & Han, A.

complete list of authors

• Park, J||Kim, S||Li, J||Han, A

publication date

• January 2014

International Standard Book Number (ISBN) 13

• 9780979806476

start page

• 150

end page

• 152