A novel TFT-driven microchannel electrophoresis device for proteins separation and identification Conference Paper uri icon

abstract

  • A new protein separation and detection device that uses an amorphous silicon (a-Si:H) thin film transistor (TFT) to drive a microchannel electrophoresis has been fabricated and investigated. Three model proteins in a mixture were separated and identified from the current vs. time curve, which could be used to calculate individual protein's mobility. This in-situ method needs no complicated protein labeling and optical scanning procedures. One of the critical issues of the microchannel electrophoresis device is the current perturbation at the early stage of the operation, which can affect the overall signal identification. When a TFT is connected to the microchannel device, it functions as a current regulator diminishing the perturbation phenomenon. Therefore, proteins can be easily identified in a short period of time. This device can be a potentially important for identifying various biomolecules.

author list (cited authors)

  • Kuo, Y., & Lee, H. H.

publication date

  • December 2005