The mammalian blastema: regeneration at our fingertips. Academic Article

abstract

• In the mouse, digit tip regeneration progresses through a series of discrete stages that include inflammation, histolysis, epidermal closure, blastema formation, and redifferentiation. Recent studies reveal how each regenerative stage influences subsequent stages to establish a blastema that directs the successful regeneration of a complex mammalian structure. The focus of this review is on early events of healing and how an amputation wound transitions into a functional blastema. The stepwise formation of a mammalian blastema is proposed to provide a model for how specific targeted treatments can enhance regenerative performance in humans.

authors

• Dawson, Lindsay
• Muneoka, Ken
• Yu, Ling

published proceedings

• Regeneration (Oxf)

altmetric score

• 1

author list (cited authors)

• Simkin, J., Sammarco, M. C., Dawson, L. A., Schanes, P. P., Yu, L., & Muneoka, K.

citation count

• 54

complete list of authors

• Simkin, Jennifer||Sammarco, Mimi C||Dawson, Lindsay A||Schanes, Paula P||Yu, Ling||Muneoka, Ken

publication date

• June 2015

publisher

• Wiley  Publisher

published in

• Regeneration  Journal

keywords

• Blastema
• Digit
• Hypoxia
• Mouse
• Regeneration
• Stem Cells
• Wound Healing

PubMed Central ID

• 27499871

Digital Object Identifier (DOI)

• 10.1002/reg2.36

start page

• 93

end page

• 105

volume

• 2

issue

• 3

URL

• http%3A%2F%2Fdx.doi.org%2F10.1002%2Freg2.36