Interference-based probe of the nano-scale topography of microparticles
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Measuring nano-scale topography of microparticles is important in microfluidic-based manufacturing settings, but high-throughput characterization could be hindered by the complex instrumentation required. Conversely, reflection interference contrast microscopy (RICM) requires a fairly simple set-up, offers high spatial/temporal resolution, and provides images embedding accurate topographic information of microscopic objects. Here we present an approach to retrieve statistics of an object's nano-scale surface topography from RICM images and illustrate its use on microspheres.