selected publications academic article Deshpande, N., & Bryk, M. (2024). Correction: Diverse and dynamic forms of gene regulation by the S. cerevisiae histone methyltransferase Set1. Current Genetics. 70(1), 2. Deshpande, N., & Bryk, M. (2023). Diverse and dynamic forms of gene regulation by the S. cerevisiae histone methyltransferase Set1. 69(2-3), 91-114. Patterson, C., Klinegardner, S., Autenrieth, R., Barry, A., Bryk, M., Johnson, M., Lench, H., & Willkinson, H. (2022). Leading a mentoring culture at a research-intensive university: The pilot program report. 6(Special Issue 15), 418-422. Deshpande, N., Jordan, R., Henderson Pozzi, M., & Bryk, M. (2022). Histone 3 lysine 4 monomethylation supports activation of transcription in S. cerevisiae during nutrient stress. Current Genetics. 68(2), 181-194. Williamson, K., Schneider, V., Jordan, R. A., Mueller, J. E., Henderson Pozzi, M., & Bryk, M. (2013). Catalytic and functional roles of conserved amino acids in the SET domain of the S. cerevisiae lysine methyltransferase Set1. PLoS ONE. 8(3), e57974-e57974. Smith, D. L., Li, C., Matecic, M., Maqani, N., Bryk, M., & Smith, J. S. (2009). Calorie restriction effects on silencing and recombination at the yeast rDNA. Aging Cell. 8(6), 633-642. Blank, H. M., Li, C., Mueller, J. E., Bogomolnaya, L. M., Bryk, M., & Polymenis, M. (2008). Correction: An Increase in Mitochondrial DNA Promotes Nuclear DNA Replication in Yeast. PLOS Genetics. 4(5), 10.1371/annotation/89355dbd-390e-463f-b804-c6. Blank, H. M., Li, C., Mueller, J. E., Bogomolnaya, L. M., Bryk, M., & Polymenis, M. (2008). An increase in mitochondrial DNA promotes nuclear DNA replication in yeast. PLOS Genetics. 4(4), e1000047-e1000047. Li, C., Mueller, J. E., Elfline, M., & Bryk, M. (2008). Linker histone H1 represses recombination at the ribosomal DNA locus in the budding yeast Saccharomyces cerevisiae. Molecular Microbiology. 67(4), 906-919. Mueller, J. E., Li, C., & Bryk, M. (2007). Isw2 regulates gene silencing at the ribosomal DNA locus in Saccharomyces cerevisiae. Biochemical and Biophysical Research Communications. 361(4), 1017-1021. Mueller, J. E., & Bryk, M. (2007). Isw1 acts independently of the Isw1a and Isw1b complexes in regulating transcriptional silencing at the ribosomal DNA locus in Saccharomyces cerevisiae. Journal of Molecular Biology. 371(1), 1-10. Li, C., Mueller, J. E., & Bryk, M. (2006). Sir2 represses endogenous polymerase II transcription units in the ribosomal DNA nontranscribed spacer. Molecular Biology of the Cell. 17(9), 3848-3859. Mueller, J. E., Canze, M., & Bryk, M. (2006). The requirements for COMPASS and Paf1 in transcriptional silencing and methylation of histone H3 in Saccharomyces cerevisiae. Genetics. 173(2), 557-567. Bryk, M., Briggs, S. D., Strahl, B. D., Curcio, M. J., Allis, C. D., & Winston, F. (2002). Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism. Current Biology. 12(2), 165-170. Briggs, S. D., Bryk, M., Strahl, B. D., Cheung, W. L., Davie, J. K., Dent, S. Y., Winston, F., & Allis, C. D. (2001). Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. Genes and Development. 15(24), 3286-3295. Bryk, M., Banerjee, M., Conte, D., & Curcio, M. J. (2001). The Sgs1 helicase of Saccharomyces cerevisiae inhibits retrotransposition of Ty1 multimeric arrays. 21(16), 5374-5388. Bryk, M., Banerjee, M., Murphy, M., Knudsen, K. E., Garfinkel, D. J., & Curcio, M. J. (1997). Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast. Genes and Development. 11(2), 255-269. Mueller, J. E., Smith, D., Bryk, M., & Belfort, M. (1995). Intron-encoded endonuclease I-TevI binds as a monomer to effect sequential cleavage via conformational changes in the td homing site. EMBO Journal. 14(22), 5724-5735. Bryk, M., Belisle, M., Mueller, J. E., & Belfort, M. (1995). Selection of a remote cleavage site by I-tevI, the td intron-encoded endonuclease. Journal of Molecular Biology. 247(2), 197-210. Bryk, M., Quirk, S. M., Mueller, J. E., Loizos, N., Lawrence, C., & Belfort, M. (1993). The td intron endonuclease I-TevI makes extensive sequence-tolerant contacts across the minor groove of its DNA target. EMBO Journal. 12(10), 4040-4041. Bryk, M., Quirk, S. M., Mueller, J. E., Loizos, N., Lawrence, C., & Belfort, M. (1993). The td intron endonuclease I-TevI makes extensive sequence-tolerant contacts across the minor groove of its DNA target. EMBO Journal. 12(5), 2141-2149. Bell-Pedersen, D., Quirk, S. M., Bryk, M., & Belfort, M. (1991). I-TEVI, THE ENDONUCLEASE ENCODED BY THE MOBILE TD INTRON, RECOGNIZES BINDING AND CLEAVAGE DOMAINS ON ITS DNA TARGET. Proceedings of the National Academy of Sciences of the United States of America. 88(17), 7719-7723. Bryk, M., & Belfort, M. (1990). Spontaneous shuffling of domains between introns of phage T4. Nature. 346(6282), 394-396. conference paper Odom, S. F., Bryk, M., Coates, C., & Andersen, K. (2022). Agricultural graduate inclusive excellence leadership community: Developing graduate students for life and career success institutional repository document Deshpande, N., Jordan, R. A., Pozzi, S. H., & Bryk, M. (2021). Insights into Transcriptional Regulation by Individual H3K4 Methylation Marks in S. Cerevisiae
principal investigator on REU Site - Summer Undergraduate Research Program in Biochemistry awarded by Directorate for Biological Sciences - (Arlington, Virginia, United States) 2020 - 2023 Studies to understand the formation and function of chromatin in highly repeated DNA sequences in eukaryotes. awarded by National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States) 2016 - 2021
co-principal investigator on REU Site: Summer Undergraduate Research Program in Biochemistry awarded by National Science Foundation - (Arlington, Virginia, United States) 2014 - 2020 REU Site: Summer Undergraduate Research Program In Biochemistry awarded by National Science Foundation - (Arlington, Virginia, United States) 2009 - 2015
teaching activities AGLS489 Hnr-sptp: Food Justice Instructor AGLS489 Sptp: Climate Justice Instructor BICH101 Perspectives In Bich And Gene Instructor BICH431 Molecular Genetics Instructor BICH491 Hnr-research Instructor BICH631 Biochemical Genetics Instructor BICH673 Gene Expression Instructor BICH681 Seminar Instructor BICH691 Research Instructor BICH697 Teaching Biochem Labs Instructor GENE101 Perspectives In Bich And Gene Instructor GENE302 Principles Of Genetics Instructor GENE431 Molecular Genetics Instructor GENE491 Hnr-research Instructor GENE673 Gene Expression Instructor GENE691 Research Instructor
chaired theses and dissertations Huning, Laura Elizabeth (2020-08). Transcriptional Activation of Eukaryotic Promoters via Zinc Finger Protein 143. Jordan, Rachel Alison (2015-12). Epigenetic Regulation of Silent Chromatin in Saccharomyces cerevisiae. Leehy, Katherine (2013-07). Dissection of the telomere complex CST in Arabidopsis thaliana. Li, Chonghua (2009-05). The role of histones and histone modifying enzymes in ribosomal dna silencing in saccharomyces cerevisiae. Williamson, Kelly M. (2012-07). The Role of Chromatin Structure and Histone Modifications in Gene Silencing at the Ribosomal DNA Locus in Saccharomyces cerevisiae.
education and training Ph.D., Albany Medical Center Hospital - (Albany, New York, United States) 1994 M.S., Albany Medical Center Hospital - (Albany, New York, United States) 1991 Wadsworth Center - (Albany, New York, United States) , Postdoctoral Training 1997
mailing address Texas A&M University Biochemistry & Biophysics 2128 TAMU College Station, TX 77843-2128 USA