Chemotaxis to the quorum-sensing signal AI-2 requires the Tsr chemoreceptor and the periplasmic LsrB AI-2-binding protein. Academic Article uri icon


  • AI-2 is an autoinducer made by many bacteria. LsrB binds AI-2 in the periplasm, and Tsr is the l-serine chemoreceptor. We show that AI-2 strongly attracts Escherichia coli. Both LsrB and Tsr are necessary for sensing AI-2, but AI-2 uptake is not, suggesting that LsrB and Tsr interact directly in the periplasm.

published proceedings

  • J Bacteriol

author list (cited authors)

  • Hegde, M., Englert, D. L., Schrock, S., Cohn, W. B., Vogt, C., Wood, T. K., Manson, M. D., & Jayaraman, A.

citation count

  • 110

complete list of authors

  • Hegde, Manjunath||Englert, Derek L||Schrock, Shanna||Cohn, William B||Vogt, Christian||Wood, Thomas K||Manson, Michael D||Jayaraman, Arul

publication date

  • February 2011