A putative Ariadne-like ubiquitin ligase is required for Dictyostelium discoideum development.
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abstract
The Dictyostelium rbrA gene encodes a putative Ariadne ubiquitin ligase. rbrA(-) cells form defective slugs that cannot phototax. Prestalk cell numbers are reduced in rbrA(-) slugs, and these prestalk cells do not localize to the tip of slugs. Chimeric slugs containing wild-type cells could phototax and form fruiting bodies.