Growing and starving Dictyostelium cells produce distinct density-sensing factors. Academic Article

abstract

• Prestarvation factor (PSF) and conditioned medium factor (CMF) are two autocrine factors produced by Dictyostelium cells. Although secreted at different times in the Dictyostelium life cycle (PSF by growing cells and CMF by starving cells), both factors are glycoproteins that are used by cells to measure their own density, and both are important in cell aggregation. To examine the relationship between PSF and CMF, a CMF antisense transformant was tested for the production of PSF during growth. Although this transformant produced extremely low levels of CMF, its production of PSF was essentially normal. We conclude that these two factors are not products of the same gene.

authors

• Gomer, Richard

published proceedings

• Dev Biol

author list (cited authors)

• Clarke, M., Dominguez, N., Yuen, I. S., & Gomer, R. H.

citation count

• 28

complete list of authors

• Clarke, M||Dominguez, N||Yuen, IS||Gomer, RH

publication date

• January 1992

publisher

• Elsevier  Publisher

published in

• Developmental Biology  Journal

keywords

• Animals
• Cell Aggregation
• Culture Media
• Dictyostelium
• Food Deprivation
• Glycoproteins

Digital Object Identifier (DOI)

• 10.1016/0012-1606(92)90147-9

start page

• 403

end page

• 406

volume

• 152

issue

• 2

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2F0012-1606%2892%2990147-9