Inhibition of murine fibrocyte differentiation by cross-linked IgG is dependent on FcRI. Academic Article uri icon


  • Monocyte-derived, fibroblast-like cells, called fibrocytes, participate in wound-healing and the formation of fibrotic lesions. Aggregated or cross-linked IgG are key effectors in infections, autoimmune diseases, anaphylaxis, and immunotherapy. Cells, including monocytes and fibrocytes, bind IgG using FcRs, and aggregated or cross-linked IgG inhibits fibrocyte differentiation. Mice have four different FcRs, and which of these, if any, mediate the cross-linked IgG effect on fibrocyte differentiation is unknown. We find that in mice, deletion of FcRI or the common signaling protein FcR significantly reduces the ability of cross-linked IgG or IgG2a to inhibit fibrocyte differentiation. Cells from FcRIIb/III/IV KO mice are still sensitive to cross-linked IgG, whereas cells from FcRI/IIb/III/IV KO mice are insensitive to cross-linked IgG. These observations suggest that IgG-mediated inhibition of fibrocyte differentiation is mediated by FcRs, with FcRI mediating most of the signaling.

published proceedings

  • J Leukoc Biol

author list (cited authors)

  • Pilling, D., Crawford, J. R., Verbeek, J. S., & Gomer, R. H.

citation count

  • 5

complete list of authors

  • Pilling, Darrell||Crawford, Jeffrey R||Verbeek, J Sjef||Gomer, Richard H

publication date

  • August 2014