Brain serum amyloid P levels are reduced in individuals that lack dementia while having Alzheimer's disease neuropathology. Academic Article

abstract

• The neuropathological signs of Alzheimer's disease (AD) include beta amyloid plaques and neurofibrillary tangles. There is a significant population of individuals that have these key hallmarks but show no signs of cognitive impairment, termed non-demented with AD neuropathology (NDAN). The protective mechanism allowing these individuals to escape dementia is unknown. Serum amyloid P (SAP) is a serum protein associated with wound repair that is elevated in the brains of Alzheimer's patients and binds to amyloid plaques. Using immunoblotting and immunohistochemistry, we evaluated SAP levels in postmortem samples of hippocampus and frontal cortex in age-matched controls, AD, and NDAN individuals. AD individuals had significantly increased SAP levels compared to normal controls, while NDAN samples had no significant difference in SAP levels compared to normal controls. Our results suggest that low levels of SAP in plaques marks the brains of individuals that escape dementia despite the presence of beta amyloid plaques and tangles.

authors

• Gomer, Richard

published proceedings

• Neurochem Res

altmetric score

• 0.5

author list (cited authors)

• Crawford, J. R., Bjorklund, N. L., Taglialatela, G., & Gomer, R. H.

citation count

• 21

complete list of authors

• Crawford, Jeffrey R||Bjorklund, Nicole L||Taglialatela, Giulio||Gomer, Richard H

publication date

• January 2012

publisher

• Springer Nature  Publisher

published in

• Neurochemical Research  Journal

keywords

• Adult
• Aged
• Aged, 80 And Over
• Alzheimer Disease
• Biomarkers
• Brain
• Dementia
• Female
• Humans
• Male
• Middle Aged
• Serum Amyloid P-component

Digital Object Identifier (DOI)

• 10.1007/s11064-011-0674-0

start page

• 795

end page

• 801

volume

• 37

issue

• 4

URL

• http%3A%2F%2Fdx.doi.org%2F10.1007%2Fs11064-011-0674-0