Serum amyloid P: a systemic regulator of the innate immune response. Academic Article

abstract

• The pentraxin SAP reduces neutrophil adhesion to ECM proteins, inhibits the differentiation of monocytes into fibrocytes, attenuates profibrotic macrophages, activates the complement pathway, and promotes phagocytosis of cell debris. Together, these effects of SAP regulate key aspects of inflammation and set a threshold for immune cell activation. Here, we present a review of SAP biology with an emphasis on SAP receptor interactions and how the effect of SAP on monocytes and macrophages has been explored to develop this protein as a therapeutic for renal and lung injuries. We also discuss how there remain many unanswered questions about the role of SAP in innate immunity.

authors

• Gomer, Richard
• Pilling, Darrell

published proceedings

• J Leukoc Biol

altmetric score

• 6.25

author list (cited authors)

• Cox, N., Pilling, D., & Gomer, R. H.

citation count

• 67

complete list of authors

• Cox, Nehemiah||Pilling, Darrell||Gomer, Richard H

publication date

• November 2014

publisher

• Oxford University Press (OUP)  Publisher

published in

• n0741-5400ISSN  Journal

keywords

• Animals
• Cell Differentiation
• Fcγ Receptors
• Fibrocyte Differentiation
• Fibrosis
• Humans
• Immunity, Innate
• Immunomodulation
• Macrophage Polarization
• Macrophages
• Mice
• Monocytes
• Neutrophil Adhesion
• Neutrophils
• Phagocytosis
• Serum Amyloid P-component

Digital Object Identifier (DOI)

• 10.1189/jlb.1MR0114-068R

start page

• 739

end page

• 743

volume

• 96

issue

• 5

URL

• http://dx.doi.org/10.1189/jlb.1mr0114-068r