Drosophila BAP60 is an essential component of the Brahma complex, required for gene activation and repression. Academic Article uri icon


  • The SWI/SNF-like chromatin remodeling complex of Drosophila, the Brahma complex, contains four subunits (Brahma, BAP155/Moira, SNR1 and BAP60) conserved from yeast to humans. A reconstituted human complex lacking the BAP60 homolog shows full remodeling activity, suggesting that BAP60 is not essential for the core function. We generated Drosophila mutants and found that BAP60 carries a vital function and participates in complex-mediated transcriptional activation and repression. BAP60 binds DNA and shows genetic and physical interactions with the sex-determining transcription factors encoded by sisterless A and scute. The results support the conclusion that BAP60 participates in site-specific recruitment of the Brahma complex in Drosophila.

published proceedings

  • J Mol Biol

author list (cited authors)

  • Mller, A., Avila, F. W., Erickson, J. W., & Jckle, H.

citation count

  • 14

complete list of authors

  • Möller, André||Avila, Frank W||Erickson, James W||Jäckle, Herbert

publication date

  • September 2005