Evaluation of amino-substituted heterocyclic derivatives as alanine racemase inhibitors Academic Article uri icon


  • A series of five-membered (5-16) and six-membered (17-21) heterocyclic compounds were evaluated for inhibitory activity against purified alanine racemases (alr gene products) from E. coli, S. aureus, P. aeruginosa, and M. tuberculosis. Three compounds (5, 6, 11) were found to exhibit moderate inhibitory activity, in agreement with a recently proposed pathway for D-cycloserine (1) function.

published proceedings


author list (cited authors)

  • Kim, M. G., Strych, U., Krause, K., Benedik, M., & Kohn, H.

complete list of authors

  • Kim, MG||Strych, U||Krause, K||Benedik, M||Kohn, H

publication date

  • December 2003