Evaluation of amino-substituted heterocyclic derivatives as alanine racemase inhibitors Academic Article

abstract

• A series of five-membered (5-16) and six-membered (17-21) heterocyclic compounds were evaluated for inhibitory activity against purified alanine racemases (alr gene products) from E. coli, S. aureus, P. aeruginosa, and M. tuberculosis. Three compounds (5, 6, 11) were found to exhibit moderate inhibitory activity, in agreement with a recently proposed pathway for D-cycloserine (1) function.

authors

• Benedik, Michael

published proceedings

• MEDICINAL CHEMISTRY RESEARCH

author list (cited authors)

• Kim, M. G., Strych, U., Krause, K., Benedik, M., & Kohn, H.

complete list of authors

• Kim, MG||Strych, U||Krause, K||Benedik, M||Kohn, H

publication date

• December 2003

published in

• MEDICINAL CHEMISTRY RESEARCH  Journal

start page

• 130

end page

• 138

volume

• 12

issue

• 3