Chrysobalanus icaco L. Anthocyanins Reduced Cell Proliferation and Inflammation in HT-29 Colon Cancer Cells Conference Paper uri icon


  • Chrysobalanus icaco L. (CI) is an anthocyaninrich fruit found in tropical areas around the globe that has not yet been widely investigated. The objective of this study was to assess the antiinflammatory and antiproliferative activities of polyphenols extracted from CI in HT29 colon cancer cells (1.0 to 20.0 mg/L GAE). The anthocyanins profile of the extract was determined by HPLCMS and identified predominantly acylated glucosides of delphinidin, cyanidin, petunidin, peonidin and malvidin. Cell proliferation was suppressed at 20.0 mg/L. This was accompanied by an increase in intracellular ROS production as well as decreased gene expression of TNF, IL1, IL6 and NFB at 20.0 mg/L. These results suggest C. icaco anthocyanins posses chemopreventive activities by reducing the cell proliferation and inflammation in human colon cancer cells and these preliminary findings should be followed up with in vivo and mechanistic studies. Financial support: CNPq.

published proceedings


author list (cited authors)

  • Venancio, V., Cipriano, P., Kim, H., Mercadante, A., Bianchi, M., Antunes, L., Talcott, S., & Talcott, S.

citation count

  • 0

complete list of authors

  • Venancio, Vinicius||Cipriano, Paula||Kim, Hyemee||Mercadante, Adriana||Bianchi, Maria de Lourdes||Antunes, Lusania||Talcott, Stephen||Talcott, Susanne

publication date

  • April 2015