Bias reduction in conditional logistic regression Academic Article uri icon


  • We employ a general bias preventive approach developed by Firth (Biometrika 1993; 80:27-38) to reduce the bias of an estimator of the log-odds ratio parameter in a matched case-control study by solving a modified score equation. We also propose a method to calculate the standard error of the resultant estimator. A closed-form expression for the estimator of the log-odds ratio parameter is derived in the case of a dichotomous exposure variable. Finite sample properties of the estimator are investigated via a simulation study. Finally, we apply the method to analyze a matched case-control data from a low birthweight study.

author list (cited authors)

  • Sun, J. X., Sinha, S., Wang, S., & Maiti, T.

citation count

  • 12

publication date

  • November 2010