Aminoacetone as the penultimate precursor to the antitumor agent azinomycin A. Academic Article

abstract

• Experiments reveal that the metabolic precursor aminoacetone is a key intermediate in the production of the antitumor agent azinomycin A relative to the structurally and functionally related agent, azinomycin B. Azinomycin A and B arise through bifurcation of the biosynthetic pathway and competition between metabolic substrates. The availability of the biosynthetic precursors in vivo, aminoacetone for azinomycin A and threonine for azinomycin B, controls the overall ratio of azinomycin A to B produced.

authors

• Watanabe, Coran

author list (cited authors)

• Sharma, V., Kelly, G. T., Foulke-Abel, J., & Watanabe, C

citation count

• 14

complete list of authors

• Sharma, Vasudha||Kelly, Gilbert T||Foulke-Abel, Jennifer||Watanabe, Coran MH

publication date

• January 2009

publisher

• American Chemical Society (ACS)  Publisher

published in

• Organic Letters  Journal

keywords

• Acetone
• Antineoplastic Agents
• Azabicyclo Compounds
• Dipeptides
• Glycopeptides
• Intercellular Signaling Peptides And Proteins
• Molecular Structure
• Naphthalenes
• Peptides

PubMed Central ID

• 19663419

Digital Object Identifier (DOI)

• 10.1021/ol9016639

start page

• 4006

end page

• 4009

volume

• 11

issue

• 17

URL

• http%3A%2F%2Fdx.doi.org%2F10.1021%2Fol9016639