Aminoacetone as the penultimate precursor to the antitumor agent azinomycin A. Academic Article uri icon

abstract

  • Experiments reveal that the metabolic precursor aminoacetone is a key intermediate in the production of the antitumor agent azinomycin A relative to the structurally and functionally related agent, azinomycin B. Azinomycin A and B arise through bifurcation of the biosynthetic pathway and competition between metabolic substrates. The availability of the biosynthetic precursors in vivo, aminoacetone for azinomycin A and threonine for azinomycin B, controls the overall ratio of azinomycin A to B produced.

author list (cited authors)

  • Sharma, V., Kelly, G. T., Foulke-Abel, J., & Watanabe, C

complete list of authors

  • Sharma, Vasudha||Kelly, Gilbert T||Foulke-Abel, Jennifer||Watanabe, Coran MH

publication date

  • January 1, 2009 11:11 AM