Effect of Ginkgo biloba (EGb 761) on differential gene expression. Conference Paper

abstract

• Supplementation of diets with plant extracts such as ginkgo biloba extract (EGb 761) (definition see editorial) for health and prevention of degenerative diseases is popular. However, it is often difficult to analyse the biological activities of plant extracts due to their complex nature and the possible synergistic and/or antagonistic effects of their components. Genome-wide expression monitoring with high-density oligonucleotide arrays provides one way to examine the molecular targets of plant extracts and may prove a useful tool in evaluating their therapeutic claims. Here, we will briefly describe some of our work on the effect of EGb 761 on differential gene expression in relation to its potential anti-carcinogenic, photoprotective and neuromodulatory properties.

authors

• Watanabe, Coran

published proceedings

• Pharmacopsychiatry

author list (cited authors)

• Rimbach, G., Wolffram, S., Watanabe, C., Packer, L., & Gohil, K.

citation count

• 14

complete list of authors

• Rimbach, G||Wolffram, S||Watanabe, C||Packer, L||Gohil, K

publication date

• June 2003

publisher

• Thieme  Publisher

published in

• Pharmacopsychiatry  Journal

keywords

• Animals
• Cells, Cultured
• Cerebral Cortex
• Chromatography, High Pressure Liquid
• Dose-Response Relationship, Drug
• Female
• Gene Expression
• Ginkgo Biloba
• Hippocampus
• Humans
• Keratinocytes
• Mice
• Oligonucleotide Array Sequence Analysis
• Plant Extracts
• Reverse Transcriptase Polymerase Chain Reaction
• Time Factors

PubMed Central ID

• 13130396

Digital Object Identifier (DOI)

• 10.1055/s-2003-40457

start page

• S95

end page

• S99

volume

• 36 Suppl 1

URL

• http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-2003-40457