In vitro biosynthesis of the antitumor agent azinomycin B. uri icon

abstract

  • [reaction: see text] Azinomycins have potential therapeutic value as antitumor agents; however, their biosynthesis is poorly understood. Here, we provide the first demonstration of a protein cell-free system capable of supporting complete in vitro biosynthesis of the antitumor agent azinomycin B. The cell-free system is utilized to probe the cofactor dependence and substrate requirements of the pathway en route to azinomycin.

author list (cited authors)

  • Liu, C., Kelly, G. T., & Watanabe, C

citation count

  • 24

complete list of authors

  • Liu, Chaomin||Kelly, Gilbert T||Watanabe, Coran MH

publication date

  • January 2006