In vitro biosynthesis of the antitumor agent azinomycin B. Academic Article

abstract

• [reaction: see text] Azinomycins have potential therapeutic value as antitumor agents; however, their biosynthesis is poorly understood. Here, we provide the first demonstration of a protein cell-free system capable of supporting complete in vitro biosynthesis of the antitumor agent azinomycin B. The cell-free system is utilized to probe the cofactor dependence and substrate requirements of the pathway en route to azinomycin.

authors

• Watanabe, Coran

author list (cited authors)

• Liu, C., Kelly, G. T., & Watanabe, C

citation count

• 24

complete list of authors

• Liu, Chaomin||Kelly, Gilbert T||Watanabe, Coran MH

publication date

• January 2006

publisher

• American Chemical Society (ACS)  Publisher

published in

• Organic Letters  Journal

keywords

• Antineoplastic Agents
• Catalysis
• Intercellular Signaling Peptides And Proteins
• Molecular Structure
• Naphthalenes
• Peptides
• Streptomyces

PubMed Central ID

• 16524269

Digital Object Identifier (DOI)

• 10.1021/ol052987l

start page

• 1065

end page

• 1068

volume

• 8

issue

• 6

URL

• http%3A%2F%2Fdx.doi.org%2F10.1021%2Fol052987l