Exploration of the molecular origin of the azinomycin epoxide: timing of the biosynthesis revealed. Academic Article uri icon


  • Streptomyces sahachiroi whole cell feeding experiments, utilizing putative precursors labeled with stable isotopes, established that the epoxide unit of the DNA cross-linked agents, azinomycin A and B, proceeds via a valine-dependent pathway and that hydroxylation and dehydration precedes formation of the terminal epoxide. Sodium 3-methyl-2-oxobutenoate, formed through a transimination reaction, was shown to be the penultimate precursor incorporated into the azinomycin epoxide.

altmetric score

  • 9

author list (cited authors)

  • Sharma, V., Kelly, G. T., & Watanabe, C

citation count

  • 27

complete list of authors

  • Sharma, Vasudha||Kelly, Gilbert T||Watanabe, Coran MH

publication date

  • January 2008