Structural basis for the recognition of para-benzoyl-L-phenylalanine by evolved aminoacyl-tRNA synthetases. Academic Article uri icon


  • (Chemical Equation Presented) Nonnatural interactions: The X-ray crystal structure of a mutant aminoacyl-tRNA synthetase that selectively recognizes para-benozyl-L-phenylalanine has been solved. This structure shows that mutations to the enzyme lead to new hydrophobic binding interactions with the unnatural amino acid, and a loss of specific hydrogen-bonding interactions with tyrosine, without a significant change in the polypeptide backbone conformation. 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

published proceedings

  • Angew Chem Int Ed Engl

author list (cited authors)

  • Liu, W., Alfonta, L., Mack, A. V., & Schultz, P. G.

citation count

  • 24

complete list of authors

  • Liu, Wenshe||Alfonta, Lital||Mack, Antha V||Schultz, Peter G

publication date

  • August 2007