The genetic incorporation of thirteen novel non-canonical amino acids. Academic Article uri icon

abstract

  • Thirteen novel non-canonical amino acids were synthesized and tested for suppression of an amber codon using a mutant pyrrolysyl-tRNA synthetase-tRNA(Pyl)(CUA) pair. Suppression was observed with varied efficiencies. One non-canonical amino acid in particular contains an azide that can be applied for site-selective protein labeling.

author list (cited authors)

  • Tuley, A., Wang, Y., Fang, X., Kurra, Y., Rezenom, Y. H., & Liu, W. R

complete list of authors

  • Tuley, Alfred||Wang, Yane-Shih||Fang, Xinqiang||Kurra, Yadagiri||Rezenom, Yohannes H||Liu, Wenshe R

publication date

  • January 1, 2014 11:11 AM