The genetic incorporation of thirteen novel non-canonical amino acids
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Thirteen novel non-canonical amino acids were synthesized and tested for suppression of an amber codon using a mutant pyrrolysyl-tRNA synthetase-tRNA(Pyl)(CUA) pair. Suppression was observed with varied efficiencies. One non-canonical amino acid in particular contains an azide that can be applied for site-selective protein labeling.
author list (cited authors)
Tuley, A., Wang, Y., Fang, X., Kurra, Y., Rezenom, Y. H., & Liu, W. R.