The genetic incorporation of thirteen novel non-canonical amino acids Academic Article uri icon

abstract

  • Thirteen novel non-canonical amino acids were synthesized and tested for suppression of an amber codon using a mutant pyrrolysyl-tRNA synthetase-tRNA(Pyl)(CUA) pair. Suppression was observed with varied efficiencies. One non-canonical amino acid in particular contains an azide that can be applied for site-selective protein labeling.

altmetric score

  • 0.5

author list (cited authors)

  • Tuley, A., Wang, Y., Fang, X., Kurra, Y., Rezenom, Y. H., & Liu, W. R.

citation count

  • 18

publication date

  • January 2014