The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of L-phenylalanine and its derivatives. Academic Article

abstract

• Using evolved pyrrolysyl-tRNA synthetase-tRNA(CUA)(Pyl) pairs, L-phenylalanine, p-iodo-L-phenylalanine and p-bromo-L-phenylalanine have been genetically incorporated into proteins at amber mutation sites in E. coli.

authors

• Liu, Wenshe
• Russell, David

published proceedings

• Mol Biosyst

altmetric score

• 3.5

author list (cited authors)

• Wang, Y., Russell, W. K., Wang, Z., Wan, W., Dodd, L. E., Pai, P., Russell, D. H., & Liu, W. R.

citation count

• 70

complete list of authors

• Wang, Yane-Shih||Russell, William K||Wang, Zhiyong||Wan, Wei||Dodd, Lindsey E||Pai, Pei-Jing||Russell, David H||Liu, Wenshe R

publication date

• March 2011

publisher

• Royal Society of Chemistry (RSC)  Publisher

published in

• Molecular Biosystems  Journal

keywords

• Amino Acyl-trna Synthetases
• Binding Sites
• Codon, Nonsense
• Escherichia Coli Proteins
• Lysine
• Models, Molecular
• Molecular Structure
• Mutation
• Phenylalanine
• Protein Engineering
• RNA, Transfer
• Stereoisomerism

PubMed Central ID

• 21234492

Digital Object Identifier (DOI)

• 10.1039/c0mb00217h

start page

• 714

end page

• 717

volume

• 7

issue

• 3

URL

• http://dx.doi.org/10.1039/c0mb00217h