Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader
- Additional Document Info
- View All
Fluorophenylalanines bearing 2-5 fluorine atoms at the phenyl ring have been genetically encoded by amber codon. Replacement of F59, a phenylalanine residue that is directly involved in interactions with trimethylated K9 of histone H3, in the Mpp8 chromodomain recombinantly with fluorophenylalanines significantly impairs the binding to a K9-trimethylated H3 peptide.
author list (cited authors)
Lee, Y., Schmidt, M. J., Tharp, J. M., Weber, A., Koenig, A. L., Zheng, H., ... Liu, W. R.