Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader Academic Article uri icon

abstract

  • Fluorophenylalanines bearing 2-5 fluorine atoms at the phenyl ring have been genetically encoded by amber codon. Replacement of F59, a phenylalanine residue that is directly involved in interactions with trimethylated K9 of histone H3, in the Mpp8 chromodomain recombinantly with fluorophenylalanines significantly impairs the binding to a K9-trimethylated H3 peptide.

altmetric score

  • 2.1

author list (cited authors)

  • Lee, Y., Schmidt, M. J., Tharp, J. M., Weber, A., Koenig, A. L., Zheng, H., ... Liu, W. R.

citation count

  • 8

publication date

  • October 2016