The nitrilimine-alkene cycloaddition is an ultra rapid click reaction. Academic Article uri icon


  • The transient formation of nitrilimine in aqueous conditions is greatly influenced by pH and chloride. In basic conditions (pH 10) with no chloride, a diarylnitrilimine precursor readily ionizes to form diarylnitrilimine that reacts almost instantly with an acrylamide-containing protein and fluorescently labels it.

published proceedings

  • Chem Commun (Camb)

altmetric score

  • 0.5

author list (cited authors)

  • Wang, X. S., Lee, Y., & Liu, W. R.

citation count

  • 39

complete list of authors

  • Wang, Xiaoshan Shayna||Lee, Yan-Jiun||Liu, Wenshe R

publication date

  • March 2014