Substrate specificity of human prolyl-4-hydroxylase.
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Proline analogs (3-F, 3-Cl, 3-Br, 3,3-cyclopropyl, 3,3-methylene, 3-Me, and 4-Me) were synthesized, incorporated into CbzGlyPheXGlyOEt, and tested as substrate analogues/mechanistic probes for the human prolyl-4-hydroxylase catalyzed hydroxylation reaction. With the exception of the 3-fluoroproline containing peptide, none of these peptides were substrates for the enzyme.
author list (cited authors)
Tandon, M., Wu, M., Begley, T. P., Myllyharju, J., Pirskanen, A., & Kivirikko, K.
complete list of authors
Tandon, M||Wu, M||Begley, TP||Myllyharju, J||Pirskanen, A||Kivirikko, K