Substrate specificity of human prolyl-4-hydroxylase. Academic Article

abstract

• Proline analogs (3-F, 3-Cl, 3-Br, 3,3-cyclopropyl, 3,3-methylene, 3-Me, and 4-Me) were synthesized, incorporated into CbzGlyPheXGlyOEt, and tested as substrate analogues/mechanistic probes for the human prolyl-4-hydroxylase catalyzed hydroxylation reaction. With the exception of the 3-fluoroproline containing peptide, none of these peptides were substrates for the enzyme.

authors

• Begley, Tadhg

published proceedings

• Bioorg Med Chem Lett

altmetric score

• 6

author list (cited authors)

• Tandon, M., Wu, M., Begley, T. P., Myllyharju, J., Pirskanen, A., & Kivirikko, K.

citation count

• 19

complete list of authors

• Tandon, M||Wu, M||Begley, TP||Myllyharju, J||Pirskanen, A||Kivirikko, K

publication date

• January 1998

publisher

• Elsevier  Publisher

published in

• Bioorganic and Medicinal Chemistry Letters  Journal

keywords

• Humans
• Hydroxylation
• Indicators And Reagents
• Molecular Structure
• Procollagen-Proline Dioxygenase
• Proline
• Structure-Activity Relationship
• Substrate Specificity

Digital Object Identifier (DOI)

• 10.1016/s0960-894x(98)00183-8

start page

• 1139

end page

• 1144

volume

• 8

issue

• 10

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2Fs0960-894x%2898%2900183-8