Substrate specificity of human prolyl-4-hydroxylase Academic Article uri icon

abstract

  • Proline analogs (3-F, 3-Cl, 3-Br, 3,3-cyclopropyl, 3,3-methylene, 3-Me, and 4-Me) were synthesized, incorporated into CbzGlyPheXGlyOEt, and tested as substrate analogues/mechanistic probes for the human prolyl-4-hydroxylase catalyzed hydroxylation reaction. With the exception of the 3-fluoroproline containing peptide, none of these peptides were substrates for the enzyme.

altmetric score

  • 6

author list (cited authors)

  • Tandon, M., Wu, M., Begley, T. P., Myllyharju, J., Pirskanen, A., & Kivirikko, K.

citation count

  • 17

publication date

  • May 1998