Mechanistic studies on prolyl-4-hydroxylase: the vitamin C requiring uncoupled oxidation.
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A deuterated substrate for the human type I prolyl-4-hydroxylase was synthesized and its V/K deuterium isotope effect was determined to be 3.4 +/- 0.2. This isotope effect was attributed to the uncoupled oxidation. A dehydroproline containing tetrapeptide was also found to stimulate the uncoupled oxidation.
author list (cited authors)
Wu, M., Moon, H. S., Pirskanen, A., Myllyharju, J., Kivirikko, K. I., & Begley, T. P.
complete list of authors
Wu, M||Moon, HS||Pirskanen, A||Myllyharju, J||Kivirikko, KI||Begley, TP