Highly stereoselective reduction of methyl ketone complexes of the chiral Lewis acid [(η5-C5H5)Re(NO)(PPh3)]+ by K(s-C4H9)3BH; synthesis of optically active secondary alcohols and derivatives Academic Article uri icon

abstract

  • Reaction of optically active ketone complexes (+)-(R)-[(η5-C5H5)Re(NO)-(PPh3)(η1-O=C(R)(CH3)]+ BF4- (R = CH2CH3, CH(CH3)2m C(CH3)3, C6H5) with K(s-C4H9)3BH gives alkoxide complexes (+)-(RS)-(η5-C5H5)Re(NO)(PPh3)-(OCH(R)CH3) (73-90%) in 80-98% de. The alkoxide ligand is then converted to Mosher esters (93-99%) of 79-98% de. © 1989.

author list (cited authors)

  • Dalton, D. M., & Gladysz, J. A.

citation count

  • 7

publication date

  • July 1989