HIGHLY STEREOSELECTIVE REDUCTION OF METHYL KETONE COMPLEXES OF THE CHIRAL LEWIS ACID [(ETA-5-C5H5)RE(NO)(PPH3)]+ BY K(SEC-C4H9)3BH - SYNTHESIS OF OPTICALLY-ACTIVE SECONDARY ALCOHOLS AND DERIVATIVES
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abstract
Reaction of optically active ketone complexes (+)-(R)-[(5-C5H5)Re(NO)-(PPh3)(1-O=C(R)(CH3)]+ BF4- (R = CH2CH3, CH(CH3)2m C(CH3)3, C6H5) with K(s-C4H9)3BH gives alkoxide complexes (+)-(RS)-(5-C5H5)Re(NO)(PPh3)-(OCH(R)CH3) (73-90%) in 80-98% de. The alkoxide ligand is then converted to Mosher esters (93-99%) of 79-98% de. 1989.