The selective activation of one methyl ketone enantioface via σ-binding to a chiral metal template: synthesis and reactivity of rhenium ketone complexes [(η 5 -C 5 H 5 )Re(NO)(PPh 3 )(η 1 -Me(R)C[double bond, length half m-dash]O)]+PF 6 –
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The title compounds (R = Me, Et, Ph) are synthesized from ketones in high yield, structurally characterized, and shown to undergo highly stereoselective nucleophilic attack; secondary alcohols can be made with 95 to ≥99% enantiomeric excess (e.e.).
author list (cited authors)
Fernández, J. M., Emerson, K., Larsen, R. D., & Gladysz, J. A.