Tails and steeds versus heads and beads - The case for fluorous phase methodology in combinatorial and parallel syntheses

The development of fluorous phase synthetic chemistry is reviewed from its recent origins in strategies for recoverable catalysts through emerging applications in high-throughput library synthesis. The roles of pony tails , (CH2)m(CF2)n-1 CF 3, as solubility control or phase labelling elements, are described. The synthesis and properties of fluorous aliphatic amines are detailed, and lead references to fluorous protecting groups and chromatographic methods are given.

Tails and steeds versus heads and beads - The case for fluorous phase methodology in combinatorial and parallel syntheses Academic Article