Tails and steeds versus heads and beads - The case for fluorous phase methodology in combinatorial and parallel syntheses Academic Article uri icon


  • The development of fluorous phase synthetic chemistry is reviewed from its recent origins in strategies for recoverable catalysts through emerging applications in high-throughput library synthesis. The roles of « pony tails », (CH2)m(CF2)n-1 CF 3, as solubility control or « phase labelling » elements, are described. The synthesis and properties of fluorous aliphatic amines are detailed, and lead references to fluorous protecting groups and chromatographic methods are given.

author list (cited authors)

  • Rocaboy, C., & Gladysz, J. A.

publication date

  • September 2000