Separation of lanthanum, hafnium, barium and radiotracers yttrium-88 and barium-133 using crystalline zirconium phosphate and phosphonate compounds as prospective materials for a Ra-223 radioisotope generator. Academic Article uri icon


  • Crystalline hybrid organic/inorganic ion exchangers based on zirconium phosphate and phosphonate compounds were evaluated for application in radium-223 generator for radiopharmaceutical applications. Various compositions were synthesized and the selectivity of these materials was determined for inactive lanthanum, hafnium and barium, and radiotracers yttrium-88 and barium-133. The hybrid materials show very efficient lanthanum/barium separation; the response for zirconium phosphate was even better. A small-scale column loaded with pelletized zirconium phosphate compound demonstrated excellent retention of (88)Y and release of (133)Ba.

published proceedings

  • Appl Radiat Isot

author list (cited authors)

  • Mller, T., Bestaoui, N., Wierzbicki, M., Adams, T., & Clearfield, A.

citation count

  • 11

complete list of authors

  • Möller, Teresia||Bestaoui, Naima||Wierzbicki, Melissa||Adams, Todd||Clearfield, Abraham

publication date

  • July 2011