Intra-hippocampal estradiol infusion enhances memory in ovariectomized rats. Academic Article uri icon


  • Ovariectomized adult Long-Evans rats received an eight-trial training session in a hippocampal-dependent hidden platform water maze task. Following trial 8, rats received an intra-hippocampal injection of estradiol in a water soluble cyclodextrin inclusion complex (1.0, 2.0 or 5.0 micrograms/0.5 microliter), or saline. Twenty-four hours later, the retention test escape latencies of rats administered post-training intra-hippocampal injections of estradiol (5.0 micrograms) were significantly lower than those of saline treated rats, indicating a memory-enhancing effect of estradiol. Injections of estradiol (5.0 micrograms) given 2 h post-training had no effect on retention, indicating a time-dependent effect of estradiol on memory storage processes.

published proceedings

  • Neuroreport

author list (cited authors)

  • Packard, M. G., & Teather, L. A.

citation count

  • 146

complete list of authors

  • Packard, MG||Teather, LA

publication date

  • January 1997