Intra-hippocampal estradiol infusion enhances memory in ovariectomized rats.

abstract

• Ovariectomized adult Long-Evans rats received an eight-trial training session in a hippocampal-dependent hidden platform water maze task. Following trial 8, rats received an intra-hippocampal injection of estradiol in a water soluble cyclodextrin inclusion complex (1.0, 2.0 or 5.0 micrograms/0.5 microliter), or saline. Twenty-four hours later, the retention test escape latencies of rats administered post-training intra-hippocampal injections of estradiol (5.0 micrograms) were significantly lower than those of saline treated rats, indicating a memory-enhancing effect of estradiol. Injections of estradiol (5.0 micrograms) given 2 h post-training had no effect on retention, indicating a time-dependent effect of estradiol on memory storage processes.

authors

• Packard, Mark

published proceedings

• Neuroreport

author list (cited authors)

• Packard, M. G., & Teather, L. A.

citation count

• 146

complete list of authors

• Packard, MG||Teather, LA

publication date

• January 1997

publisher

• Wolters Kluwer  Publisher

published in

• NeuroReport  Journal

keywords

• Analysis Of Variance
• Animals
• Autoradiography
• Estradiol
• Female
• Hippocampus
• Maze Learning
• Memory
• Neurons
• Ovariectomy
• Ovary
• Rats

Digital Object Identifier (DOI)

• 10.1097/00001756-199709290-00004

start page

• 3009

end page

• 3013

volume

• 8

issue

• 14

URL

• http%3A%2F%2Fdx.doi.org%2F10.1097%2F00001756-199709290-00004