The dopaminergic mesencephalic projections to the hippocampal formation in the rat.

abstract

• 1. The dopaminergic mesencephalic neurons projecting to the hippocampal formation are distributed in three cell groups: A8 region in the retrorubral field, A9 region in the substantia nigra and A10 region in the ventral tegmental area. 2. Anterograde and retrograde tract-tracing techniques combined with immunohistochemical procedures indicate a topographical organization of mesencephalic dopaminergic projections towards the hippocampal formation. 3. Electrophysiological evidence suggest that dopaminergic mesencephalic neurons could have a regulatory role in suppressing hippocampal excitability. 4. The functional significance of the mesohippocampal dopaminergic system is largely unknown, although it was suggested that this projection could have a role in methamphetamine-produced hypermotility and in modulation of memory processes.

authors

• Packard, Mark

published proceedings

• Prog Neuropsychopharmacol Biol Psychiatry

author list (cited authors)

• Gasbarri, A., Sulli, A., & Packard, M. G.

citation count

• 227

complete list of authors

• Gasbarri, A||Sulli, A||Packard, MG

publication date

• January 1997

publisher

• Elsevier  Publisher

published in

• Progress in Neuro-Psychopharmacology and Biological Psychiatry  Journal

keywords

• Animals
• Dopamine
• Hippocampus
• Mesencephalon
• Rats

Digital Object Identifier (DOI)

• 10.1016/s0278-5846(96)00157-1

start page

• 1

end page

• 22

volume

• 21

issue

• 1

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2Fs0278-5846%2896%2900157-1